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The practical challenge has always been that conventional retinol formulations can irritate the skin, potentially undermining the repair environment that copper peptides are trying to create

Molecular Aspects of Medicine, 2009

These findings indicate that antioxidant agents in the aqueous humor reflect glaucomatous optic nerve damage and that excessive oxidative stress may be involved in the pathogenesis of glaucoma

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Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN (2014) Toxicity, mechanism and health effects of some heavy metals