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In addition, in vivo, decreased occludin levels in combination with increased claudin-2 and claudin-15 36 might in synergy result in the observed increased barrier leakiness in CIA mice

Unlike most other c-Met antibodies, it destroys the productive dimerization and activation induced by HGF or c-Met on the cell surface independent of ligand (Wang et al., 2016)

Furthermore, western blot was used to analyze the protein levels of representative senescent markers, including p16, p21, and p53

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