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doi: 10.1172/JCI74915 85 MaidaAZotaASjbergKASchumacherJSijmonsmaTPPfenningerAet al

Combination therapy can lead to improved efficacy, faster results, and reduced potential for antibiotic resistance, which can occur when antibiotics are used as a monotherapy

It is used morning and evening

Grade 3 and above TRAEs which were predominantly hematologic in nature, were able to be effectively managed with standard supportive measures including dose reductions, as demonstrated by the TRAE leading to discontinuation rate of 5.0%

2.1 Paths to metabolite alteration Pesticide residues in plants lead to both direct and indirect changes in metabolite profiles