It is also recognized that smoke exposure leads to the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome [63], with consequent local generation of active interleukin 1 (IL-1), a process that induces inflammation and thereby can lead to both chronic fibrosis and cancer in mice [64]
Flouris et al., in a study on the short-term impact of active and passive use of nicotine-containing ECs versus conventional tobacco, found similar cotinine levels in users as in conventional tobacco smokers, with most changes occurring in smokers
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