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In healthy mitochondria, SIRT3 interacts with ATP5O, while the low pH owing to the loss of membrane potential weakens the binding affinity between SIRT3 and ATP5O, leading to the redistribution of SIRT3 to other mitochondria substrates

Remaining actives after 5 days of screening (n=3)

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It is not a drug, food, cosmetic, or dietary ingredient and must not be used on humans or animals

Only the dry lyophilizate is stored in the freezer before reconstitution

In FOXO4-DRI (D-retro-inverso-isoform peptide), L-amino acids are substituted by D-amino acids that mimic the FOXO4 p53 binding domain