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In clinical practice, individualized drug regimens need to be developed based on patient-specific conditions, and therapeutic drug monitoring and individualized genetic testing are effective tools to increase the efficacy and decrease the adverse effects of metformin for PCOS therapy

In addition, the hippocampus showed considerable increases in tau phosphorylation, A protein deposition, and cell death

Subcutaneous administration of vitamin B12 is sometimes employed, especially in patients with congenital cobalamin metabolism disorders who require high doses to maintain normal metabolic pathways

Three DNA adducts were detected after incubation with CHE and calf thymus deoxyribonucleic acid (CT-DNA) in the presence of SpragueDawley rat liver microsomes and nicotinamide adenine dinucleotide phosphate (NADPH) (Stiborov et al., 2002)

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