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SAM and SAH show pathway activity Low SAM and elevated SAH represent different biochemical barriers and should not automatically receive the same treatment

The hydroperoxides upon binding to catalytic motif oxidize selenolate into selenenic acid (RSeOH) and are concurrently reduced into corresponding water/alcohol molecules (Fig

Circ Res 2002

Bibcode:1993NaGen...5..327B

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The dose of NAC was chosen according to our published studies ( gpx1 / + NAC group compared with the peroxynitrite + gpx1 / group (Figure 6B)