Besides being the sole antioxidant enzyme able to repair lipid peroxides, GPX4 is a moonlighting protein that also regulate eicosanoid biosynthesis ( Hydroperoxides relevant to inflammation are those formed from arachidonic acid (AA) by stereoselective lipoxygenases
[9,10,22,24,25,27,28,42, 43, 44, 45, 46] The target immune cells in this strategy are autoreactive T cells, regulatory T cells (T regs ), and tolerogenic dendritic cells (tol DCs), as schematized in Figure 1 for SLE
Vitamin K: food composition and dietary intakes
This fuels a vicious cycle of oxidative stress, senescence, and fibrosis, exacerbating disease progression
The pathogenesis of COPD remains unclear and has been generally suggested to be related to inflammation, oxidative stress, protease/anti-protease imbalance and decreased immunity
PMID: 91 WeiMLiJYanHLuoTHuangJYuanYet al