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Mechanistically, sorafenib suppresses system Xc-, which promotes ER stress, GSH depletion, and the iron-dependent accumulation of lipid ROS (Dixon et al., 2014)

FEBS Lett 97:138140 Wei AC, Aon MA, ORourke B, Winslow RL, Cortassa S (2011) Mitochondrial Energetics, pH Regulation, and Ion Dynamics: a Computational-Experimental Approach

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