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2 Previously described as a harmless metabolic byproduct, it is now implicated in the pathogenesis of cardiovascular disease (CVD), chronic kidney disease (CKD), and other metabolic syndromes

doi: 10.1136/gutjnl-2015-309957 177 BarreaLAnnunziataGMuscogiuriGLaudisioDDi SommaCMaistoMet al

In addition, clofazimine is an affordable treatment for patients with COVID-19, which may help to relieve the acute healthcare burden created by the pandemic in lower-income countries 19

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Additionally, thioredoxin-1, a core component of the thioredoxin system, also contributes to these protective effects by maintaining cellular redox balance (237, 238)

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