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NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability

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Similarly, fisetin, a flavonoid found in strawberries and other fruits, activates SIRT1 by increasing NAD + levels while also reducing oxidative stress and inflammation 179 (Fig

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These findings suggest possible protective mechanisms against oxidative stress and apoptosis in vascular and macrophage cells