According to a peer-reviewed review in the International Journal of Molecular Sciences on peptides as therapeutic agents for inflammatory-related diseases, which describes how peptides can selectively modulate inflammatory signals such as cytokines and NF-kB, this targeted signaling is exactly why peptides are being studied so heavily as anti-inflammatory agents
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Table 1 Ferroptosis modulators
Furthermore, astrocyte-derived HO has been shown to activate Nrf2, reinforcing antioxidative responses 87
Storm-Mathisen et al., 1992), and thus also in astrocytic mitochondria, will not be affected, because mitochondrial glutamate is re-established via MAS-mediated uptake, initial transamination to -ketoglutarate, coupled to transamination of oxaloacetate, and a second transamination coupled to GABA transaminase-mediated formation of SSA
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