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Their mechanisms of action are summarized in Figure 3 , and the classification, molecular targets, and known resistance mechanisms are listed in Table 1

Small amounts of melatonin are found in fruits, nuts, olive oil and wine

WD: Validation, Writing review & editing, Funding acquisition, Project administration

The regimen emphasizes stage-specific interventions: early-stage management combines A-clearing agents (e.g., aducanumab) with ferroptosis inhibitors (e.g., sulforaphane via Nrf2/GPX4 activation) to reduce A plaques and counteract oxidative stress/lipid peroxidation

Futile cycles: emerging utility from apparent futility

Heres whats emerged: In early rodent models, Dihexa was found to significantly increase synapse formationmore so than BDNF itself