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Biomaterial-based delivery systems (hydrogels) have been shown to be excellent carriers that enhance cell/drug localization, survival and therapeutic efficacy in organ injury repair

However, when apoptosis occurs, p53 may inhibit PHGDH transcription and reduce unnecessary serine synthesis (Ou et al., 2015)

Researchers monitoring animal models or in vitro systems should anticipate these metabolic shifts and incorporate appropriate measurements into their study protocols

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