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In the liver, adiponectin increases insulin sensitivity by decreasing the expression of hepatic gluconeogenic enzymes (phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) and the rate of endogenous glucose production

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Beyond this window, peptide degradation through oxidation and aggregation accelerates even under refrigerated conditions, leading to progressive loss of receptor binding activity

Although the peak-to-trough olanzapine fluctuation for OLAI was found to be no greater than the fluctuation for a daily oral dose, the convenience of a once-monthly injection needs to be balanced against a possible decrease in efficacy at the end of a 4-week injection interval during the trough concentrations or the potential risk for a higher incidence or greater severity of adverse events early in the injection interval near the peak concentrations

Rehman et al., 2017