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However, in several Phase III trials, Rituximab failed to meet its primary efficacy endpoints
Treatment using XO inhibitors showed a mild protective effect on renal function in patients with hypertension (Kohagura et al
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They also reported that these patients had higher levels of interleukin 1 (IL-1), IL-6, and TNF- , suggesting an inflammatory state and oxidative stress in migraine patients (112)
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