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Future studies will focus on the functional validation of these novel loci, including the integration of ocular-specific eQTL and gene expression data to elucidate the precise mechanisms, contribute to glaucoma pathogenesis

In a large trial, semaglutide 2.4 mg led to about 14.9% mean body-weight loss at 68 weeks versus 2.4% with placebo

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In brain tissue, misfolded proteins such as amyloid-beta and tau can sequester copper ions, creating local copper deficiency while simultaneously generating reactive oxygen species through aberrant metal-protein interactions