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The dopaminergic neurons of park 13 and wild type control flies were marked with TH-Gal4 driven expression of UAS-GFP

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To explore whether epigenetic regulation contributes to the basal repression of MAPKAPK2, in silico CpG island prediction using MethPrimer identified dense CpG motifs within the MAPKAPK2 promoter region (Figure 1D), implicating potential DNA methylationmediated regulation