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The authors speculated that increased GSH reflected a compensatory response to ongoing inflammatory processes related to brain injury

Biofilm cells exhibit collective phenotypes that differ from planktonic cells including altered metabolism, increased stress response, altered cell surface properties, and the secretion of a protective extracellular matrix (ECM) creating a niche environment, together all these factors contribute to their enhanced tolerance to antifungal therapy and immune clearance (Nett and Andes, 2020

Conversely, ferroptosis-related release of oxidized byproducts and iron ions feeds back to escalate inflammation and further damage cartilage and synovium, establishing a vicious cycle