Glutamate and glycine, the other two precursors, are generally not limiting
Some regenerative medicine protocols combine peptide therapy with other treatments such as PRP, stem cells, exosomes, and IV therapy
CoQ10 has very strong antioxidant activity, which protects against free radical damage
Exposure to heat can quickly degrade the vitamin, making it less effective
Thus, these evidences suggest c-MET to be a good target to be used in respect to CAR-T cell therapy in cancer patients
As a side note, the observed modest response for the DMSO control was also incorporated into the model to take into account that a minor part of the pathway activation observed under the experimental conditions used is due to DMSO rather than DEM (see Supplement)