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More than half of the patients were former smokers (12 of 23, 52%), and the average BMI was 35.32 kg/m 2 , classified as class II obesity, with 70% (16/23) being obese

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39 proteoforms deriving from 25 parent genes were significantly associated with cognitive resilience and frailty, including proteoforms of VGF, SST, CCK and CHGA/B

This leads to an increase in osmotic pressure, disrupting the typical morphology of hippocampus neurons and causing a gradual decline in neurological function

Sequence: Y-Aib-E-G-T-F-T-S-D-Y-S-I-L-L-D-K-Aib-A-Q-Aib-A-F-I-E-Y-L-L-E-G-G-P-S-S-G-A-P-P-P-S-NH2