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doi: 10.1155/2016/2795090 269 TangC.-F.DingH.JiaoR.-Q.WuX.-X.KongL.-D

The glutamate residues are added by an amide linkage to the -carboxylate group of the folate derivative

Despite the unprecedented progress in understanding the pathogenesis and treatment of RA, unresolved challenges remain, particularly in terms of functional impairment