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Current research indicates that the cell cycle arrest depends on the activity of cyclin-dependent kinase inhibitors (CDK) p16 and p21, often regulated by the main tumor suppressor protein p53, whose elevated level is frequently used as a marker of senescence detection [21]

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Jacob Puzey offered a defense Tuesday, arguing that McKnight lacked the anti-doping education and team guidance many college and professional runners receive and saying he didnt believe McKnight intentionally sought an unfair advantage