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The addition of homocysteine causes some proteins to become pro-inflammatory or pro-thrombotic.[ref] Oxidative stress, ER stress, and mitochondrial dysfunction: High homocysteine levels are also associated with increased oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress

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Toxicol Appl Pharmacol 247:211221 Griffith OW, Meister A (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)