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Another rat study found that acute restraint stress can upregulate TLR4 gene expression in the frontal cortex by inducing gut microbiota translocation, while intervention with antibiotics or the TLR4 specific inhibitor TAK-242 effectively suppresses this process and reduces the accumulation of inflammatory and oxidative/nitrosative mediators (163)

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Another important pathway of arginine metabolism is the generation of NO catalyzed by NOS, which was previously defined as a critical regulator of tumor immunity

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Narrowing of the spinal canal puts pressure on nerve roots