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Release of presynaptic glutamate and activation of postsynaptic glutamate receptors on the postsynaptic neuron stimulate influx of Na + and Ca 2+ ions into the postsynaptic neuron, which contributes to depolarization and action potentials ( Glutamate Transporters and Receptors Excitatory Amino Acid Transporters Increased levels of extracellular glutamate, particularly asynchronistic glutamate levels, cause cellular damage when excitatory neurotransmission is sufficiently aberrant (Pitt et al., 2000

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doi: 10.1016/j.phrs.2023.106930

However, in regard to bacterial selenoproteins, the stem-loop structure has to be located immediately downstream of the UGA codon of the selenoprotein coding genes

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injection When given i.v., its onset of action is ~1 minute When given i.m