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Metabolism and amyloid clearance rely to a large extent on mitochondria, which during neurodegeneration are deteriorating (Phillipson, 2017
Recent studies have reported the various strategies used to inhibit glutamine metabolism have discrete effects on CD8 + T cells, emphasizing that targeting the same pathway with different modes may result in conflicting metabolic and functional consequences, further highlighting the importance of understanding how glutamine precisely affects the metabolic pathways and functional dynamics of different immune cell subpopulations in TME [224]
In the MED12m fibroid subtype, significant dysregulation of the antioxidant pathway of vitamin C was found in fibroid samples based on both metabolic and gene expression levels [78]
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The final products of these pathways, glutamate and pyruvate or acetate, are released by CAFs and can be exploited opportunistically by cancer cells [67]
The dissociation process was terminated with fresh complete DMEM medium
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