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In some embodiments, the otic formulation or composition comprises about 1% by weight of the cholesterol

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Research demonstrates that TB-500 forms functional complexes with PINCH-1 and integrin-linked kinase (ILK) that can inhibit TNF--induced NF-B activation through blocking RelA/p65 translocation, providing rapid suppression of inflammatory transcriptional programs

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Understanding the evidence, safety considerations, and lack of proven synergistic benefit is essential for informed clinical decision-making when patients consider combining these treatments