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However, vast intra- and interfamilial variability tells a much wider clinical presentation [4,5,6] and an important overlap with other EDS subtypes and HCTDs [1, 9, 16, 28,29,30]

Victories by anti-tobacco advocates would add to a surge that has already raised tens of billions of dollars for states while helping drive down the nation's smoking rate, from about a quarter of adults in 1990 to fewer than 17 percent in the most recent surveys