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6 Discussion Synthesizing the foregoing evidence, this article proposes a central hypothesis of ferroptosis in periodontitis: ferroptosis is not merely a passive accompaniment to disease progression, but has the potential to evolve into an important node and signal amplification link within the pathological network

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Alternatively, ensure adequate dietary intake of sulfur-rich foods (cruciferous vegetables, garlic, onions) and the amino acids needed for GSH synthesis (whey protein is particularly rich in cysteine)

Inhibiting NNMT has been proposed as a therapeutic strategy for metabolic disease