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Some sports fans and analysts think that nicotine is a performance-enhancing drug (PED)

Holman wants them to be informed about smoke-free options that are significantly better than combustible cigarettes

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Also, nicotine significantly induces vascular smooth muscle cells proliferation via the upregulation of bFGF mitogen and several MMPs, which leads to an augmentation of lesions and development of intimal hyperplasia, atherosclerosis, and aneurysm