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Chai, H

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Integrating ChIP-seq, HiC, and PRO-seq datasets, we revealed broad functional binding of NRF2 at enhancer elements, including NRF2-dependent enhancer-derived RNA (eRNA) synthesis and extensive linkages between NRF2 target promoters and enhancers

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Modules correlated with the KO genotype were enriched for neuronal and synaptic genes involved in vesicle-mediated transport, neurotransmitter secretion, and GTPase activity, suggesting that RAMP deletion disrupts synaptic signaling networks critical for metabolic regulation [2]

J Biol Chem 271, 1350413514 (1996)