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437 , 213845 (2021) Lawson, H.D., Walton, S.P., Chan, C.: Metalorganic frameworks for drug delivery: a design perspective

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Activated caspase-8 subsequently triggers caspase-3, leading to cell death

Moreover, in patients with CKD, vanadate has also been observed to prompt eryptosis by inhibiting ATP production, thus resulting in energy deficit [259]

doi: 10.1016/j.vaccine.2011.06.109 184

Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1