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Response timelines depend on sleep issue severity, underlying causes (stress, circadian disruption, aging, etc.), genetic sleep factors, concurrent sleep hygiene practices, protocol adherence, and dosing optimization
The 100mg daily dose provides maximum NNMT inhibition while remaining within established safety parameters
10.1016/j.neuroimage.2015.11.039 Neuroimage 49 FrancisF.KoulakoffA.BoucherD.ChafeyP.SchaarB.VinetM
Mar 2006;26(1):67-97, viii
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