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Human immunodeficiency virus1 causes neurological disorders, including cognitive decline and dementia in 4060% of patients, even with tri-therapy (Anthony et al., 2017) has been linked to neurological disorders (Chaganti et al., 2019)

In the muscle tissues of murine CLI models, similar increases in the expression of CD31, -smooth muscle actin (-SMA), Ang2, tie2, VEGFA, N1ICD, and p-p65 were observed, suggesting a regulatory potential of TB-500 on these molecular targets

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APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes