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With six exons and multiple transcription sites, IGF-1 can be spliced into two classes consisting of three major isoforms each (IGF-1Ea, IGF-1Eb, IGF-1Ec) for a total of at least six different proteins

Epithelial-mesenchymal transition (EMT), a critical pathological phenomenon in cancer development and metastasis, permeates the entire process of gastric cancer initiation, progression, and dissemination

Ota K., Dohi Y., Brydun A., Nakanome A., Ito S., Igarashi K., Antioxid Redox Signal 2011, 14, 2441

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Research on these peptides is also contributing to a deeper understanding of angiogenesis, cell migration, vascular signaling, and regenerative processes, which may ultimately support the development of future therapeutic strategies

Beil W, Obst B, Sewing KF, Wagner S