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Activation of the Nrf2/HO-1 Pathway Restores N-Acetylcysteine-Induced Impairment of the Hypothalamus-Pituitary-Adrenal Axis Negative Feedback by up-Regulating GR Expression and down-Regulating GR Expression into Pituitary Glands

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The addition of catalase to the incubation prevented the detection of hydrogen peroxide, 325 51 vs 1653 189 (arbitrary fluorescence of DCF/ml) at 60 minutes of incubation under the conditions described in Fig

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Cohorts were injected at 3 months with either Gsto2 -shRNA or scrambled shRNA (Fig