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Alcohol is a significant cause of rhabdomyolysis, a condition marked by severe muscle tissue damage

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Synthesis of aryl-fused bicyclo[3.1.1]heptanes and validation as naphthyl bioisosteres

GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]

Reduced glutathione (GSH) is a tripeptide (g-glutamylcysteinylglycine) and plays a key role in preventing oxidative damage in living organisms

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