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In patients with progressive myoclonus epilepsy, a GSTT1 -null genotype has been associated with increased risk of developing the disease where it might contribute to enhanced susceptibility to oxidative stress 60

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1 General effects Antioxidant NAC contains a thiol (sulfhydryl, -SH) group that can interact with reactive oxygen species (ROS

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Seleninic or selenol intermediates generated from the oxidation/reduction of DSePA can follow the analogous catalytic steps as discussed for the native GPx enzyme in the earlier section to detoxify the hyperoxides by consuming the thiols [82, 83]