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Typically, those on a vegan diet or suffer from a health condition such as malabsorption benefit greatly from Vitamin B12 injections, as they find it difficult to reach the recommended dietary allowance

PMID: 23692737

Severe insulin resistance / T2D : low doses may be less clinically visible, so the model can push the target upward, but it still builds through the lower adaptation rungs

After initial correction, some individuals may require ongoing maintenance injections (often monthly) if they cannot adequately absorb B12 from diet or oral supplements

While true deficiency can cause serious problems, many people end up taking doses far higher than they need

Published 2020 Sep 15