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Activated NFE2L2 induces a broad antioxidant program, including genes involved in GSH synthesis, regeneration, and utilization ( e.g

27 Decreased expression of xCT leads to an increase in the rate of sulphur transfer from homocysteine to cysteine (through the trans-sulphuration branch of the methionine cycle), supporting the pivotal role of xCT in cyst(e)ine transport and cysteine provision

A 2025 nationwide cohort study of more than 91,000 matched COPD patients found that long-term NAC use was associated with a lower overall cancer risk compared with non-NAC mucolytic use

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Mitochondrial integrated stress response controls lung epithelial cell fate