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During oxidative stress, modifications in cysteine residues on Keap1 release Nrf2, allowing it to translocate into the nucleus, bind to AREs in target genes, and initiate transcription of essential antioxidant genes 67

10.1097/00006534-200005000-00019 [DOI] [PubMed] [Google Scholar] Numata Y., Terui T., Okuyama R., Hirasawa N., Sugiura Y., Miyoshi I., et al

It is thought to involve aberrant immune responses but is not classified as a typical autoimmune disorder

Pharmaceuticals 17(8):975 Rosiak N, Tykarska E, Cielecka-Piontek J (2024) Enhanced antioxidant and neuroprotective properties of pterostilbene (resveratrol derivative) in amorphous solid dispersions