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This was along with counteraction of clopidogrel-induced down-regulation of the VEGF-A and VEGFR1 , subsequently inactivated AKT signaling pathway, and induced phosphorylation of p38/MAPK and ERK/MAPK [92]

Kurozumi S, Kaira K, Matsumoto H, Kurosumi M, Yokobori T, Kanai Y, et al

Mangiferin acts as a competitive inhibitor of THF, binding favorably to SHMT in a manner similar to THF and inhibiting SHMT activity [172]

SNAP-tag is a protein tag that forms a highly stable covalent thioether bond with a fluorophore or other substituent group when appended to benzylguanine

This method offers a costeffective and scalable solution for largescale peptide production, making it a promising approach for developing foodderived antiobesity peptides (Gao et al., 2021)