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It plays a role in the angiogenesis and vasculogenesis processes, where it regulates the expression of key molecules on the cell surface to modulate cell adhesion and motility 42

doi: 10.1212/wnl.0000000000207156 13 AndoY.NakamuraM.KaiH.KatsuragiS.TerazakiH.NozawaT.et al

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Within the last years, it became evident that renal tubular ferroptosis, a modality of regulated necrosis caused by iron-dependent lipid peroxidation [3], is a pathophysiological hallmark of IRI, raising considerable interest in the development of preventive strategies upon solid organ transplantation [4]

Inhibition of human osteoclast differentiation by kynurenine through the aryl-hydrocarbon receptor pathway

Genetics, environmental factors, infections, and even some medications might play a role