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Assay of 8-isoprostane Urinary isoprostane, a parameter of oxidative stress, was measured by enzyme immunoassay (Cayman Chemical Company, Ann Arbor, MI) [12]

Since synergy demands a higher standard than simple overlap, its evaluation requires comparisons between combinations and individual peptides, standardized injury models, and predefined evaluation criteria (migration assays, histology, collagen organization, vascular markers, inflammatory markers, and functional metrics)

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The graveyard of neuroprotection and neurorestoration is full of compounds that improved rat stroke scores and then failed in humans