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Cardiac-targeted nanoparticles, low-dose pulses, or intermittent regimens could enhance bioavailability and efficacy while reducing systemic exposure and toxicity

Patients with genetic variants associated with reduced B12 absorption or increased metabolic demand often benefit most from methylcobalamin (more bioavailable) or intramuscular administration, rather than standard oral cyanocobalamin

After reviewing many clinical trials, the authors concluded beta-sitosterol may help to normalize blood glucose and insulin levels, improve glycemic control, improve lipid profiles (due to its cholesterol lowering properties), and lower markers of oxidative stress

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