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Future research should prioritize elucidating dynamic iron transport mechanisms across the blood-brain barrier, validating combination therapies targeting synergistic ferroptosis regulators (e.g., Nrf2/GPX4/FSP1), and advancing preclinical findings toward biomarker identification and precision intervention protocols
The main sources of ROS under physiological conditions include the mitochondrial respiratory chain, peroxisomes, NADPH oxidase (NOX), and lipoxygenase (ALOX), and additional ROS-producing enzymes, such as cyclooxygenases (COXs) and cytochrome p450s (CYPs) [12, 13]
T. Huanget al., Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro, Informa UK Limited, Apr. 2015. doi: 10.2147/dddt.s82030
Palm lined streets connect boutiques, restaurants, and shaded plazas, and the day unfolds at an easy, social pace from morning coffee through evening dining
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