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or (3) GSH/CG at 10 mM (thus for experiment 3 the total concentration of ligand was 20 mM) and then cryo-protected using sequential addition of glycerol from 10 to 25% (v/v)

Mahler M, Bogdanos DP, Pavlidis P, Fritzler MJ, Csernok E, Damoiseaux J, et al

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Watson et al

Sharma S, Shrivastava S, Shukla S (2013) Reversal of lead-induced toxicity due to the effect of antioxidants

Phase (approx.) Cagrilintide dose Frequency Weeks 14 0.25 mg Once weekly Weeks 58 0.5 mg Once weekly Weeks 912 1.0 mg Once weekly Weeks 1316 1.7 mg Once weekly Week 17 onward 2.4 mg (max studied) Once weekly This step-wise schedule mirrors the titration used in cagrilintide and CagriSema studies ( Lau et al., Lancet 2021