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17(12): CR677CR682 Janet K

In particular, Eadesgroup in 2011 identified and validated for the first time in MDA-MB-231 and Hs578T breast cancer cells a miRNA, miR-200a, able to target the KEAP1 3-untranslated region (3-UTR), leading to KEAP1 mRNA degradation and, consequently, NRF2 stabilization and translocation to the nucleus [178]

Its expression is induced by arsenite (AsIII), amino acid depletion, and the pollutant perfluorooctane sulfonate (Hamano et al., 2020

however, the weight loss does not always happen evenly over 23-day period

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