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For example, ER stress activates DNA damage inducible transcript 3 (DDIT3, also known as CHOP)- and mitogen-activated protein kinase 8 (MAPK8, also known as JNK)-dependent apoptosis pathways, whereas heat shock protein family A member 5 (HSPA5, also known as BIP) SSG at Cys420/441 modulates ATPase activity and protein folding, paradoxically suppressing apoptosis 49

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Medication helped for a while, but over time it became less effective

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Proc Natl Acad Sci U S A (1998) 95:132905.10.1073/pnas.95.22.13290 157 BowleyMPDrevetsWCOngurDPriceJL